Epigenomics and immunotherapeutic advances in pediatric brain tumors
نویسندگان
چکیده
منابع مشابه
Immunotherapeutic implications of the immunophenotype of pediatric brain tumors
The cytofluorometric analysis of dissociated tumor samples identified distinct immunophenotypes among the most common variants of pediatric brain tumor. These findings suggest that immunotherapeutic regimens against pediatric brain malignancies should be tailored to individual tumor types.
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Central nervous system (CNS) cancers are the second most frequent malignancy (and the most common solid tumor) in childhood. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have improved survival in children with these tumors. However, a significant proportion of patients with CNS tumors suffer progressive disease despite such treatment. Advances in the understa...
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Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...
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ژورنال
عنوان ژورنال: npj Precision Oncology
سال: 2021
ISSN: 2397-768X
DOI: 10.1038/s41698-021-00173-4